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Kikuchi-Fujimoto disease associated with mixed connective tissue disease
N Pallet1, L Aaron, F Larousserie
1Department of Infectious and Tropical Diseases, Hopital Necker-Enfants Malades, Paris, France.
Abstract:
Kikuchi-Fujimoto disease is characterized by painful cervical lymphadenopathy and constitutional symptoms. Microscopical study of lymph nodes shows focal areas of non-suppurative necrosis with histiocytic and plasmacytoid cell infiltrates. The course is usually benign. Often primitive, necrotising histiocytic lymphadenopathy may be associated with autoimmune disorders. We describe the case of a 30-year-old female patient with two 15-day courses of Kikuchi-Fujimoto disease flares within a period of 3 months, occurring in association with mixed connective tissue disease.
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