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Published on: April 7, 2017
Investigations on prolonged release of vitamin C formulations
1Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100-Tandoğan - Ankara - Turkey.
Abstract:
In this study, investigations have been carried out to prepare prolonged release formulations of ascorbic acid in order to obtain a more effective dissolution profile of the drug. For the preparation of micropellets, the fluid bed method was chosen and to obtain prolonged effect, aqueous dispersions of Eudragit S, L and their mixtures were used. After setting the parameters of fluid bed, micropellets were produced using different coating dispersions. Following the production process, morphology, friability, particle size distribution, flow properties, bulk density and dissolution tests were carried out on the micropellets. The most appropriate formulation for our aim was chosen according to these tests.
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