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Octanol-water partition coefficient of glucose, sucrose, and trehalose
María F Mazzobre1, María V Román, Ariel Feo Mourelle
1Unidad de Actividad Química, Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, Av. General Paz 1499 (1650), San Martín, Buenos Aires, Argentina. mazzobre@cnea.gov.ar
Abstract:
The octanol-water partition coefficients (P) of glucose, sucrose, and trehalose were measured at temperatures between 5 and 20 degrees C using an enzymatic method. The measured log P is compared with calculated and experimental data previously reported. In the case of trehalose, the measured log P differs considerably from the theoretically estimated values and agrees with the expected value for a disaccharide. Some methods of assessing the partition coefficients are also analyzed and it is concluded that the atom/fragment contribution method overestimates the hydrophilicity of disaccharides and, probably in a larger extension, that of trisaccharides. The knowledge of P for these sugars is valuable both for basic or applied purposes, including food and biomolecules stabilization.
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