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The rat brain hippocampus proteome.

Michael Fountoulakis¹, George T Tsangaris, Antony Maris

¹F. Hoffmann-La Roche Ltd., Center for Medical Genomics, Basel, Switzerland. mfountoulakis@bioacademy.gr

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences

|March 31, 2005

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Researchers created a comprehensive rat hippocampus proteome database, identifying 148 gene products including enzymes and neuron-specific proteins. This resource aids neurological disorder research using animal models.

Area of Science:

Neuroscience
Proteomics
Biochemistry

Background:

The hippocampus is vital for memory and stress response.
Hippocampal CA1 pathology is an early sign of Alzheimer's disease.
A complete hippocampus proteome analysis is lacking.

Purpose of the Study:

To construct a comprehensive two-dimensional database of rat brain hippocampus proteins.
To provide a valuable resource for neurological disorder research.

Main Methods:

Proteomics technologies were employed.
Two-dimensional electrophoresis was used for hippocampus samples from 8-month-old rats.
Proteins were identified using matrix-assisted laser desorption ionization time-of-flight mass spectrometry.

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Main Results:

A database of 148 distinct gene products was established.
The majority of identified proteins are enzymes, structural proteins, and heat shock proteins.
39 neuron-specific gene products were identified.

Conclusions:

The developed rat hippocampus proteome database is a significant resource.
This database can advance studies on neurological disorders using animal models.