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Bioactive Peptides in Greek Goat Colostrum: Relevance to Human Metabolism.

Maria Louiza Petre1, Anna Nefeli Kontouli Pertesi1, Olympia Eirini Boulioglou1

  • 1Department of Biotechnology, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.

Foods (Basel, Switzerland)
|December 17, 2024
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Colostrum, rich in bioactive peptides, significantly impacts human metabolism by influencing the renin-angiotensin system and insulin secretion. This study reveals Greek goat colostrum

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bioactive peptidescolostrummetabolismproteomics

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Area of Science:

  • Nutritional Biochemistry
  • Proteomics
  • Human Metabolism

Background:

  • Colostrum is a vital nutrient source for neonates, promoting immunity and growth.
  • It contains higher protein and peptide content than mature milk, with functional properties linked to bioactive peptides.
  • The role of colostrum-derived bioactive peptides in human metabolism requires comprehensive analysis.

Purpose of the Study:

  • To analyze the whey proteome of Greek goat colostrum.
  • To investigate the influence of colostrum-derived bioactive peptides on human metabolism.
  • To identify specific peptides and their metabolic targets, including those affecting the renin-angiotensin system and insulin secretion.

Main Methods:

  • NanoLC-MS/MS analysis of colostrum and mature milk proteins from ewes.
  • Functional characterization of differentially expressed proteins.
  • In silico digestion, machine learning for peptide classification, and molecular docking for binding affinity assessment (ACE and DPPIV inhibition).

Main Results:

  • Identified 898 proteins in colostrum, with 40 overexpressed compared to mature milk.
  • Generated 117 peptides predicted to impact human metabolism via renin-angiotensin system, insulin secretion, and redox pathways.
  • Confirmed potential ACE- and DPPIV-inhibitory activities of specific bioactive peptides.

Conclusions:

  • Greek goat colostrum is a rich source of bioactive peptides with significant metabolic implications for humans.
  • These peptides can modulate key metabolic pathways, suggesting potential health benefits.
  • This research enhances understanding of dietary bioactive peptides and their role in human health.