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Photo-onycholysis: two cases induced by doxycycline
T Badri1, N Ben Tekaya, F Cherif
1Department of Dermatology, Rabta Hospital, 1007 Tunis, Tunisia. talel_badri@yahoo.fr
Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica
|April 9, 2005
Summary
Photo-onycholysis, a nail separation caused by UV light and often drug-induced, can occur with doxycycline. This condition typically resolves within months after stopping the medication.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Photo-onycholysis is a phototoxic reaction characterized by nail separation from the nail bed upon ultraviolet radiation exposure.
- This reaction is frequently associated with certain medications, including tetracyclines, psoralens, and fluoroquinolones.
Purpose of the Study:
- To report two cases of photo-onycholysis in female patients treated with doxycycline.
- To highlight doxycycline as a potential causative agent for photo-onycholysis.
Main Methods:
- Case report of two female patients.
- Clinical observation of nail changes and patient medication history.
Main Results:
- Both patients developed distal onycholysis while on doxycycline therapy.
- The observed photo-onycholysis presented as distal, half-moon shaped nail separation, sometimes with surrounding pigmentation.
Conclusions:
- Doxycycline can induce photo-onycholysis, a condition that typically presents distally and may be pigmented.
- Discontinuation of the causative drug leads to spontaneous recovery of photo-onycholysis within months.