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[Does therapeutic membrane plasmapheresis increase protein synthesis?].

K Opatrný1, V Spustová, Z Rusavý

  • 1Interní oddĕlení Strahov, Praha.

Casopis Lekaru Ceskych
|March 23, 1992
PubMed
Summary

Therapeutic membrane plasmapheresis was found to accelerate protein synthesis. This was evidenced by an increased serum pseudouridine (PSI) to creatinine ratio, indicating faster tRNA turnover during the procedure.

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Area of Science:

  • Biochemistry
  • Physiology

Context:

  • Therapeutic membrane plasmapheresis is a medical procedure used to remove plasma components.
  • Understanding its systemic effects on cellular metabolism is crucial.

Purpose:

  • To investigate whether therapeutic membrane plasmapheresis influences protein synthesis.
  • To assess the impact of plasmapheresis on tRNA turnover as an indirect marker of protein synthesis.

Summary:

  • Plasmapheresis procedures were performed using specific filters to exchange one plasma volume.
  • Pseudouridine (PSI), a marker for tRNA turnover, was measured before, during, and after plasmapheresis.
  • While renal clearance of PSI decreased post-procedure due to reduced glomerular filtration, the serum PSI/creatinine ratio significantly increased, suggesting accelerated protein synthesis.

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Impact:

  • This study provides evidence that therapeutic membrane plasmapheresis enhances protein synthesis.
  • The findings suggest a potential metabolic benefit of plasmapheresis beyond its primary therapeutic goals.