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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

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Related Experiment Video

Updated: Jul 26, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

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[Acquired palmoplantar keratoderma with hypothyroidism].

María Dolores Salduna1, Carolina Fux, Ricardo Albertini

  • 1Servicio de Dermatología, Hospital Privado de Córdoba, Argentina. hdv@tutopia.com

Medicina
|April 16, 2005
PubMed
Summary

Severe hypothyroidism can cause acquired palmoplantar keratoderma, a skin condition affecting the hands and feet. Thyroid hormone replacement therapy can reverse these skin lesions, highlighting an unusual but treatable association.

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Area of Science:

  • Dermatology
  • Endocrinology
  • Internal Medicine

Background:

  • Acquired palmoplantar keratoderma is a rare condition characterized by thickening of the skin on the palms and soles.
  • Hypothyroidism, particularly chronic thyroiditis with severe hypothyroidism, can present with various dermatological manifestations.

Observation:

  • A 45-year-old male presented with palmoplantar hyperkeratosis.
  • The patient had a history of chronic thyroiditis and severe hypothyroidism.

Findings:

  • Skin lesions, specifically palmoplantar keratoderma, showed significant improvement following thyroid hormone replacement therapy.
  • Complete resolution of the palmoplantar keratoderma was observed after seven months of consistent thyroid hormone treatment.

Implications:

  • This case suggests that acquired palmoplantar keratoderma, though unusual, should be considered in the differential diagnosis of hypothyroidism.
  • The findings underscore that this dermatological manifestation of hypothyroidism is a reversible condition with appropriate endocrine management.