Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sperm-mediated gene transfer: applications and implications.

Kevin Smith1, Corrado Spadafora

  • 1School of Contemporary Sciences, University of Abertay, Dundee, UK. k.smith@tay.ac.uk

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|April 16, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cephalotaxinone enzymes reveal a whole plant model for homoharringtonine biosynthesis.

Nature chemical biology·2026
Same author

Research integrity and transparency in CAM journals: an analysis of publication bias and reporting practices (1995-2023) in four leading journals.

Research integrity and peer review·2026
Same author

Strengthening the Physician Workforce: An Expert Panel Discussion.

The Permanente journal·2026
Same author

Exploring the potential of naked barley to manage deoxynivalenol accumulation from Fusarium head blight.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2026
Same author

Case Report and Epidemiological Investigation of Healthcare-associated <i>Plasmodium falciparum</i> Malaria Transmission in Westchester County, New York-2023.

Open forum infectious diseases·2025
Same author

Streamlining the Histopathologic Workflow in Diabetic Kidney Disease with Artificial Intelligence.

Journal of the American Society of Nephrology : JASN·2025
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

Sperm-mediated gene transfer (SMGT) shows potential for animal transgenesis, but outcomes vary. Sperm may carry genetic material, influencing offspring and potentially natural evolutionary processes.

Area of Science:

  • Reproductive Biology
  • Genetics
  • Molecular Biology

Background:

  • Sperm cells are increasingly recognized as potential vectors for transferring exogenous genetic sequences.
  • Sperm-mediated gene transfer (SMGT) offers possibilities for animal transgenesis.
  • The fate of transferred genetic material via SMGT is not always predictable.

Purpose of the Study:

  • To review the current understanding of sperm-mediated gene transfer (SMGT).
  • To explore the mechanisms and implications of exogenous genetic sequence transfer by sperm.
  • To consider the potential for SMGT in natural evolutionary processes.

Main Methods:

  • Review of existing scientific literature on sperm-mediated gene transfer.
  • Analysis of studies investigating the integration and inheritance of foreign sequences in SMGT-derived offspring.

Related Experiment Videos

  • Identification of factors mediating SMGT, including endogenous reverse transcriptase.

    • Main Results:

    • SMGT can lead to the transfer of exogenous genetic sequences by sperm.
    • Offspring from SMGT may show integrated foreign sequences or lack detectable genomic modification.
    • Inheritance patterns suggest extrachromosomal structures may be involved in SMGT outcomes.
    • Endogenous reverse transcriptase plays a significant role in SMGT.
    • Environmental conditions, like those in assisted reproduction, can compromise sperm's natural protection against foreign nucleic acids.

    Conclusions:

    • SMGT is a viable concept for animal transgenesis, though outcomes require further investigation.
    • The potential for sperm to carry and transfer genetic material has implications for host genome integrity.
    • SMGT events might occur naturally, influencing evolutionary trajectories.