[Sensomotor cortex ultrastructure in pubertal offspring of alcoholized male rats]

Neuron, astrocyte and capillary ultrastructure was studied in the sensomotor cortex of 3-month-old offspring of the alcoholized male rats that received 8 g of alcohol prepared as 50% solution per kg of body weight once daily for 4 weeks. In addition to the signs of delayed maturation of neuronal and glial cell processes, some cortical areas demonstrated the destructive changes in a certain portion of neurons and elements of compensatory-adaptive processes in the others. Membranous and myelin-like intranuclear inclusions and marked Golgi complex changes were the characteristic features of the damaged cortical neuronal population. Astrocyte swelling, capillary deformation with their ultrastructural changes, accumulation of atypical inclusions in pericapillary astrocyte processes result in deterioration of bilateral blood-neuronal exchange. Possible role of ischemia-hypoxia factor in long-term disturbances in sensomotor cortex ultrastructure in the offspring of alcoholized male rats is emphasized.