Related Experiment Video

Updated: Aug 8, 2026

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
11:23

Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

Published on: May 22, 2012

Inhibition of the cell cycle with chemical inhibitors: a targeted approach

Julie P I Welburn1, Jane A Endicott

  • 1Laboratory of Molecular Biophysics and Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK. welburn@biop.ox.ac.uk

Seminars in Cell & Developmental Biology
|April 21, 2005
PubMed

Insights

Small molecules targeting cell cycle deregulation show promise for cancer treatment. Advances in understanding cell cycle control and protein structure enable rational drug design for clinical applications.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Oncology

Background:

  • Established genetic links exist between cell cycle deregulation and cancer.
  • Recent advancements have deepened the understanding of molecular mechanisms controlling cell cycle progression.

Purpose of the Study:

  • To review small molecules designed to modulate cell cycle progression.
  • To highlight the potential of these compounds as future cancer therapeutics.

Main Methods:

  • Rational design of small molecules based on protein structure determination at atomic resolution.
  • Focus on compounds competing for protein-protein or protein-ATP interactions.

Main Results:

  • Development of small molecules that rationally target cell cycle control mechanisms.
  • Identification of compounds with potential for clinical significance in cancer therapy.

Conclusions:

  • Significant optimism exists for the clinical application of rationally designed cell cycle modulators.
  • These compounds represent a promising new avenue for cancer drug development.

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