Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emergency interventions for hyperkalaemia.

B A Mahoney, W A D Smith, D S Lo

    The Cochrane Database of Systematic Reviews
    |April 23, 2005
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Frequency-Dependent Squeezed Vacuum Source for the Advanced Virgo Gravitational-Wave Detector.

    Physical review letters·2023
    Same author

    Photo Quiz: Therapeutic Contact Lens-Associated Fungal Keratitis.

    Journal of clinical microbiology·2023
    Same author

    Answer to July 2023 Photo Quiz.

    Journal of clinical microbiology·2023
    Same author

    Tools for assessing health research partnership outcomes and impacts: a systematic review.

    Health research policy and systems·2023
    Same author

    Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

    Physical review letters·2022
    Same author

    Chronic ozone exposure preferentially modifies root rather than foliar metabolism of date palm (Phoenix dactylifera) saplings.

    The Science of the total environment·2021
    Same journal

    Interventions to prevent or cease electronic cigarette use in children and adolescents.

    The Cochrane database of systematic reviews·2026
    Same journal

    Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

    The Cochrane database of systematic reviews·2026
    Same journal

    Interventions for smoking cessation in inpatient psychiatry settings.

    The Cochrane database of systematic reviews·2026
    Same journal

    Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

    The Cochrane database of systematic reviews·2026
    Same journal

    Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

    The Cochrane database of systematic reviews·2026
    Same journal

    Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

    The Cochrane database of systematic reviews·2026
    See all related articles

    Emergency hyperkalemia management is best supported by inhaled beta-agonists or intravenous insulin-and-glucose. Combining these therapies may offer superior efficacy for severe cases, with IV calcium recommended for arrhythmias.

    Area of Science:

    • Nephrology
    • Emergency Medicine
    • Pharmacology

    Background:

    • Hyperkalemia affects 1-10% of hospitalized patients and can lead to fatal arrhythmias.
    • Prompt management of hyperkalemia is crucial to prevent severe complications.

    Purpose of the Study:

    • To review randomized controlled trial (RCT) evidence for acute hyperkalemia management.
    • To identify effective interventions for emergency treatment of elevated potassium levels.

    Main Methods:

    • Systematic literature search of MEDLINE, EMBASE, and Cochrane Library (1966-2003).
    • Inclusion of randomized, quasi-randomized, or cross-over studies on non-neonatal human hyperkalemia.
    • Data extraction focused on potassium levels within six hours, arrhythmias, mortality, and adverse effects.

    Related Experiment Videos

    Main Results:

    • Inhaled beta-agonists and intravenous insulin-and-glucose demonstrated effectiveness in lowering serum potassium.
    • Combination therapy of nebulized beta-agonists with IV insulin-and-glucose showed enhanced efficacy.
    • Dialysis proved effective; IV bicarbonate results were equivocal, and K-absorbing resin was ineffective within four hours.

    Conclusions:

    • Nebulized salbutamol and IV insulin-and-glucose are evidence-based first-line treatments for emergency hyperkalemia.
    • Combination therapy is recommended for severe hyperkalemia.
    • Intravenous calcium is suggested for managing hyperkalemia-associated arrhythmias based on existing data.