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Updated: Aug 18, 2026
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[Preliminary study on autoregulation of samR involved in development and differentiation of Streptomyces
Yan-ling Yang1, Hai-hua Yang, Hua-rong Tan
1Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China. yanghh@sun.im.ac.cn
Abstract:
The previous result showed that samR plays an important role in the development progress of Streptomyces ansochromogenes. It was reported that the differentiation progress of S. ansochromogenes was accelerated by a recombinant plasmid containing an extra copy of samR gene. However, the differentiation progress of S. ansochromogenes was not further accelerated by a multicopy plasmid containing samR gene. Electrophoresis mobility shift assay (EMSA) demonstrated that SamR binds to its own promoter region specifically. All these results hint that samR is an autoregulatory gene in Streptomyces ansochromogenes.
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