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Updated: Aug 18, 2026
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Application of molecular diagnostic techniques to renal epithelial neoplasms
Timothy D Jones1, John N Eble, Liang Cheng
1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana University Medical Center, University Hospital, Indianapolis, IN 46202, USA.
Abstract:
The application of molecular and cytogenetic techniques to the study of renal neoplasia has resulted in improved understanding of the biologic mechanisms that are responsible for tumor development and progression. It also revealed that several different and specific genetic events are responsible for tumorigenesis in the various categories and subcategories of renal tumors. The ultimate goal of research on the molecular pathology of renal neoplasms is a complete understanding of the genetics of these tumors, which will, in turn, aid in making the correct diagnosis, accurately assessing prognosis, and selecting appropriate and targeted therapeutic options.
Insights
Molecular and cytogenetic techniques enhance understanding of renal neoplasia development and progression. Identifying specific genetic events aids in accurate diagnosis, prognosis, and targeted therapies for kidney tumors.
Area of Science:
- * Renal neoplasia research.
- * Molecular pathology.
- * Cytogenetics.
Background:
- * Molecular and cytogenetic techniques have advanced the study of renal neoplasia.
- * These methods have improved understanding of tumor development and progression mechanisms.
- * Specific genetic events are implicated in various renal tumor categories.
Purpose of the Study:
- * To elucidate the genetic underpinnings of renal tumors.
- * To advance the molecular pathology of kidney neoplasms.
- * To facilitate improved diagnosis, prognosis, and targeted therapy selection.
Main Methods:
- * Application of molecular techniques.
- * Utilization of cytogenetic analysis.
- * Investigation of genetic events in renal tumorigenesis.
Main Results:
- * Improved understanding of biologic mechanisms in renal tumor development.
- * Identification of distinct genetic events across different renal tumor subtypes.
- * Established links between genetic alterations and tumor progression.
Conclusions:
- * Molecular and cytogenetic studies are crucial for understanding renal neoplasms.
- * Knowledge of specific genetic events is key to classifying renal tumors.
- * Comprehensive genetic understanding will guide clinical management, including diagnosis, prognosis, and therapy.
