Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Waste not, want not--transcript excess in multicellular eukaryotes.

Jürgen Brosius1

  • 1Institute of Experimental Pathology, ZMBE, University of Münster, Von-Esmarch-Str. 56, Münster, Germany. RNA.world@uni-muenster.de

Trends in Genetics : TIG
|April 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment.

Nature communications·2025
Same author

GPR15 differentially regulates the effects of cigarette smoke exposure on Crohn's disease and ulcerative colitis.

Signal transduction and targeted therapy·2025
Same author

Constitutively active glucagon receptor drives high blood glucose in birds.

Nature·2025
Same author

S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity.

Nature communications·2025
Same author

ExoPLOT: Representation of alternative splicing in human tissues and developmental stages with transposed element (TE) involvement.

Genomics·2022
Same author

Enhancer occlusion transcripts regulate the activity of human enhancer domains via transcriptional interference: a computational perspective.

Nucleic acids research·2020
Same journal

Reading another hidden message in the genetic code.

Trends in genetics : TIG·2026
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
See all related articles

Mammalian genomes produce numerous non-protein-coding RNAs, some with regulatory roles. However, the function of all transcripts is debated, with some potentially arising from random transcription or alternative splicing, offering evolutionary potential.

Area of Science:

  • Genomics
  • Molecular Biology
  • RNA Biology

Background:

  • Mammalian genomes generate thousands of non-protein-coding RNA (ncRNA) transcripts.
  • The complexity of ncRNAs may rival that of messenger RNAs (mRNAs).
  • Some ncRNAs are known to play crucial regulatory roles within cells.

Purpose of the Study:

  • To investigate whether all transcribed RNAs possess a function.
  • To explore the possibility that many transcripts are products of non-functional, fortuitous transcription.
  • To consider the evolutionary implications of non-functional transcripts and alternative splicing events.

Main Methods:

  • Analysis of genomic data to identify and quantify various RNA transcripts.
  • Comparison of protein-coding and non-protein-coding RNA populations.

Related Experiment Videos

  • Bioinformatic approaches to assess the potential functionality and evolutionary origin of transcripts.

    • Main Results:

    • Evidence suggests a vast number of transcripts do not encode proteins.
    • The functional significance of the majority of these ncRNAs remains uncertain.
    • Alternative splicing can produce non-functional truncated proteins, analogous to non-functional RNAs.

    Conclusions:

    • Not all transcripts may have a defined cellular function.
    • Aberrant transcripts and processing products can represent evolutionary raw material.
    • These 'non-functional' RNAs offer novel substrates for natural selection to act upon.