Related Experiment Video

Updated: Aug 18, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

Genetic study of ICAM1 in clinical malaria in Senegal

R Ndiaye1, A Sakuntabhai, I Casadémont

  • 1Génétique des Maladies Infectieuses et Autoimmunes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, France.

Tissue Antigens
|April 28, 2005
PubMed

Insights

This study investigated the intercellular adhesion molecule 1 (ICAM1) gene's role in severe malaria risk. Genetic analysis in Senegalese villages found no evidence that ICAM1 variants influence malaria susceptibility or severity.

Area of Science:

  • Genetics
  • Immunology
  • Infectious Diseases

Background:

  • Severe malaria risk is linked to numerous genes, but findings for intercellular adhesion molecule 1 (ICAM1) variants are conflicting.
  • In vitro studies suggest a functional role for the ICAM1(Kilifi) variant in malaria, yet in vivo evidence remains unclear.

Purpose of the Study:

  • To investigate the implication of ICAM1 genetic variability in malaria susceptibility and resistance.
  • To understand the clinical relevance of ICAM1 in malaria pathogenesis, focusing on parasite density and attack frequency.

Main Methods:

  • Conducted linkage and association studies of the full ICAM1 genetic variability.
  • Analyzed ICAM1 variants against clinical malaria phenotypes in two endemic Senegalese villages.

Main Results:

  • No statistical evidence was found linking ICAM1 genetic variability to malaria phenotypes.
  • The study did not support a role for ICAM1 in determining parasite density or the number of malaria attacks.

Conclusions:

  • ICAM1 genetic variations do not appear to play a significant role in the studied malaria phenotypes in this population.
  • Further research may be needed to fully elucidate the complex genetic underpinnings of malaria susceptibility.

More Related Videos

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages08:23

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice12:48

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Published on: January 2, 2013

Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...