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Delayed contrast-enhanced MRI of the aortic wall in Takayasu's arteritis: initial experience

Milind Y Desai1, John H Stone, Thomas K F Foo

  • 1Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

AJR. American Journal of Roentgenology
|April 28, 2005
PubMed
Abstract

Insights

Delayed contrast-enhanced MRI can identify inflammation in patients with Takayasu's arteritis. This technique may reveal arterial wall inflammation, especially in patients with abnormal lab results.

Area of Science:

  • Cardiovascular Imaging
  • Inflammatory Diseases
  • Radiology

Background:

  • Takayasu's arteritis is a rare inflammatory condition affecting large arteries.
  • Inflammation and fibrosis characterize the arterial wall in Takayasu's arteritis.
  • Delayed contrast-enhanced MRI is a developing tool for cardiac viability assessment.

Purpose of the Study:

  • To evaluate the utility of delayed contrast-enhanced MRI in patients with Takayasu's arteritis.
  • To assess for evidence of arterial wall inflammation using this imaging technique.

Main Methods:

  • Seven patients with diagnosed Takayasu's arteritis underwent delayed (20 min) gadolinium-enhanced MRI.
  • An inversion recovery prepared gated fast gradient-echo pulse sequence was utilized.

Main Results:

  • Delayed hyper-enhancement was observed in patients with Takayasu's arteritis.
  • Findings were particularly noted in patients with abnormal laboratory values.

Conclusions:

  • Delayed contrast-enhanced MRI demonstrates potential for identifying arterial wall inflammation in Takayasu's arteritis.
  • This imaging modality may serve as a valuable tool for assessing disease activity.

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