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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Published on: December 15, 2011

[Clinical picture of celiac disease in children]

Urszula Grzybowska-Chlebowczyk1, Halina Woś, Sabina Wiecek

  • 1Klinika Pediatrii Slaskiej Akademii Medycznej, Górnoślaskie Centrum Zdrowia Dziecka i Matki w Katowicach. klinikapediatrii@ślam.katowice.pl

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|April 30, 2005
PubMed

Insights

Celiac disease in children often presents with few or no symptoms, despite significant intestinal damage. Early diagnosis is crucial, even without clear clinical signs, to manage this gluten-induced autoimmune disorder.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Gastroenterology

Context:

  • Celiac disease incidence is shifting towards asymptomatic and oligosymptomatic forms.
  • Atypical presentations and extraintestinal manifestations are increasingly observed in children and adults.
  • Clinical symptoms can manifest at any age, including latent forms triggered by various factors.

Purpose:

  • To present the diverse clinical presentations of celiac disease in pediatric patients.
  • To highlight the challenges in diagnosing celiac disease when typical symptoms are absent.

Summary:

  • A study evaluated 16 children (12 months to 17 years) diagnosed with celiac disease via clinical, histopathological, and immunological methods.
  • The most frequent diagnosis was silent, monosymptomatic celiac disease, with some presenting with growth retardation, osteoporosis, or anemia.
  • Notably, 3 patients had gastrointestinal symptoms and histopathological changes but lacked immunological markers for celiac disease.

Impact:

  • Celiac disease in school-aged children frequently lacks obvious clinical disorders despite significant histopathological abnormalities.
  • This underscores the importance of considering celiac disease in pediatric patients with subtle or atypical symptoms.
  • Highlights the diagnostic challenges posed by cases with discordant clinical, immunological, and histopathological findings.
Abstract

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