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Related Experiment Videos

Measles.

David Elliman1, Nitu Sengupta

  • 1Islington PCT and Great Ormond Street Hospital, London, UK. ellimd@gosh.nhs.uk

Current Opinion in Infectious Diseases
|May 3, 2005
PubMed
Summary
This summary is machine-generated.

High measles-containing vaccine uptake can eliminate measles, but safety concerns persist. Further research is needed to address vaccine hesitancy and understand vaccine failure.

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Area of Science:

  • Immunology
  • Epidemiology
  • Public Health

Background:

  • Measles remains a significant public health concern globally, despite advances in vaccination.
  • Vaccine uptake significantly impacts measles control, with regional variations observed.

Purpose of the Study:

  • To review key publications on measles disease and measles-containing vaccines from 2004.
  • To assess the effectiveness of measles vaccination strategies and identify challenges.

Main Methods:

  • Literature review of scientific papers published in 2004.
  • Synthesis of findings related to measles epidemiology, vaccine efficacy, and safety.

Main Results:

  • Measles is controlled in the Americas and Europe due to high two-dose vaccine uptake.

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  • Low vaccine uptake, as seen in Japan, correlates with continued measles morbidity and mortality.
  • Primary vaccine failure, potentially linked to HLA type, is a key factor in vaccine failure.
  • Measles-containing vaccines are linked to febrile convulsions but not strongly to atopy or autism.

    • Conclusions:

    • Measles elimination is achievable with high two-dose vaccine coverage.
    • Addressing parental and professional concerns regarding vaccine safety is crucial for maintaining high uptake.
    • Further research is necessary to improve vaccine effectiveness and understand vaccine failure mechanisms.