Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytomegalovirus.

Paul D Griffiths1, Simone Walter

  • 1Centre for Virology, Royal Free and University College Medical School, London, UK. p.griffiths@medsch.ucl.ac.uk

Current Opinion in Infectious Diseases
|May 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Utero MR Imaging for Fetuses with Small Head Sizes without Intracranial Abnormalities Detected on Ultrasonography.

AJNR. American journal of neuroradiology·2025
Same author

Early investigation of sensorineural hearing loss enables diagnosis of rare metabolic diseases, such as mucopolysaccharidosis type III.

BMJ case reports·2025
Same author

Early Congenital Cytomegalovirus Detection Pathways in Pediatric Audiology Services in England: Findings From a National Audit in England.

The Pediatric infectious disease journal·2024
Same author

Consensus Definitions of Cytomegalovirus (CMV) Infection and Disease in Transplant Patients Including Resistant and Refractory CMV for Use in Clinical Trials: 2024 Update From the Transplant Associated Virus Infections Forum.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2024
Same author

What are the neurodevelopmental outcomes of children with asymptomatic congenital cytomegalovirus infection at birth? A systematic literature review.

Reviews in medical virology·2024
Same author

Vaccine value profile for cytomegalovirus.

Vaccine·2023
Same journal

Use of gloves: current evidence vs. current use.

Current opinion in infectious diseases·2026
Same journal

Understanding challenges to prevention of healthcare related infections.

Current opinion in infectious diseases·2026
Same journal

Harnessing next-generation microbial diagnostics to optimize infection management in immunocompromised hosts.

Current opinion in infectious diseases·2026
Same journal

Epidemiology, treatment and outcomes of antimicrobial-resistant infections in hematopoietic stem cell transplant recipients.

Current opinion in infectious diseases·2026
Same journal

Dengue and chikungunya vaccines past, present and future: implications for travelers.

Current opinion in infectious diseases·2026
Same journal

Oropouche virus: viral evolution, epidemiological trends, and challenges for control.

Current opinion in infectious diseases·2026
See all related articles

Recent advances in congenital cytomegalovirus (CMV) management include ganciclovir treatment for hearing loss and dried blood spot testing for diagnosis. CMV vaccines are also in development, potentially making congenital CMV vaccine-preventable.

Area of Science:

  • Virology
  • Neonatalogy
  • Immunology

Background:

  • Congenital cytomegalovirus (CMV) infection significantly impacts infant neurodevelopment.
  • Current management strategies for congenital CMV are limited.
  • There is a critical need for improved diagnostic and therapeutic interventions.

Purpose of the Study:

  • To review recent advancements in the diagnosis and management of congenital cytomegalovirus (CMV) infection.
  • To highlight progress in therapeutic interventions and vaccine development for congenital CMV.
  • To assess the potential for preventing congenital CMV through vaccination.

Main Methods:

  • Review of recent randomized controlled trials on ganciclovir treatment for congenital CMV.
  • Evaluation of diagnostic techniques using stored dried blood spots for CMV DNA detection.

Related Experiment Videos

  • Analysis of preclinical and early clinical data from cytomegalovirus vaccine candidates.

    • Main Results:

    • Ganciclovir treatment significantly reduces hearing loss in neonates with congenital CMV and central nervous system involvement.
    • Dried blood spot analysis allows differentiation of congenital from perinatal CMV infection and aids in diagnosing idiopathic developmental issues.
    • Vaccine candidates, including glycoprotein B constructs, show promise in preclinical and early human trials, demonstrating immunogenicity and tolerability.

    Conclusions:

    • Significant progress has been made in congenital CMV diagnosis and treatment.
    • Ganciclovir should be considered for neonates with proven congenital CMV and CNS involvement.
    • With adequate funding for clinical trials, congenital CMV could become a vaccine-preventable disease.