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Related Experiment Videos

Multi-centre investigation on reference ranges for ROTEM thromboelastometry.

Thomas Lang1, Anne Bauters, Siegmund L Braun

  • 1Clinical Institute of Medical and Chemical Laboratory Diagnostic, University Clinic of Graz, Austria.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|May 5, 2005
PubMed
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Reagent-supported thromboelastometry (ROTEM) provides consistent results across multiple centers for monitoring bleeding disorders. This study establishes reference ranges for key TEM tests, aiding point-of-care diagnostics.

Area of Science:

  • Clinical diagnostics
  • Haematology
  • Point-of-care testing

Background:

  • Thromboelastography (TEG) and thromboelastometry (TEM) are vital for monitoring acute bleeding.
  • ROTEM is an enhanced method for point-of-care assessment of coagulation disorders.
  • Establishing reliable reference ranges is crucial for accurate interpretation of TEM results.

Purpose of the Study:

  • To determine the reference ranges for INTEM, EXTEM, and FIBTEM tests using the ROTEM analyzer.
  • To assess the inter-center variability of these ROTEM-based coagulation parameters.
  • To evaluate the influence of sex and age on ROTEM results and sample stability.

Main Methods:

  • Multi-center investigation of reagent-supported thromboelastometry (TEM) using the ROTEM Whole Blood Haemostasis Analyser.

Related Experiment Videos

  • Analysis of activated (INTEM, EXTEM) and fibrin-specific (FIBTEM) coagulation tests.
  • Evaluation of clotting time (CT), clot formation time (CFT), alpha angle (ALP), and maximum clot firmness (MCF).

    • Main Results:

    • Comparable reference ranges were obtained across centers for INTEM, EXTEM, and FIBTEM tests.
    • INTEM: CT 137-246s, CFT 40-100s, MCF 52-72mm. EXTEM: CT 42-74s, CFT 46-148s, MCF 49-71mm. FIBTEM: MCF 9-25mm.
    • Weak correlations observed with sex and age; citrated samples stable up to 6 hours.

    Conclusions:

    • ROTEM thromboelastometry demonstrates consistent performance across different centers.
    • General, orientating reference ranges for TEM tests can be established.
    • These findings support the use of ROTEM for reliable point-of-care monitoring of perioperative bleeding.