Related Experiment Video
Updated: Aug 18, 2026
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Unusual clinical presentation of regression in a congenital melanocytic nevus
Nicola Arpaia1, Nicoletta Cassano, Raffaele Filotico
1MIDIM Department, University of Bari, Bari, Italy.
Background:
Regression of congenital melanocytic nevi is usually accompanied by the halo phenomenon and is considered a rare event.
Objective:
A 15-year-old woman presented for the evaluation of multiple halo nevi. She had on her trunk a figure-of-eight pigmentary lesion, which had been developed after the coalescence of two distinct congenital melanocytic nevi. Close to the indentation between the two portions of the lesion, there was an achromic rounded area, extending from the perinevic skin to the nevus, causing its partial regression.
Methods And Materials:
Dermoscopic examination disclosed a globular and homogeneous pattern, which was irregularly present at the edge of the achromic area. The histopathologic diagnosis was compound congenital melanocytic nevus with an eccentric area of regression.
Conclusions:
In our case, the presence of a regression area in the surrounding skin and the association with multiple halo nevi suggest a similarity with halo phenomenon, despite the atypical "halo," which was discontinuous and eccentric.
Related Concept Videos
01:30Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
02:23Abnormal Proliferation
02:23Abnormal Proliferation
01:19Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
01:11Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...