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[Sentinel node biopsy without systematic axillary dissection: study about 1000 procedures].

S Giard1, M-P Chauvet, J-L Houpeau

  • 1Département de sénologie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020 Lille cedex, France. sylvia.giard@wanadoo.fr

Gynecologie, Obstetrique & Fertilite
|May 17, 2005
PubMed
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Sentinel node (SN) biopsy is a reliable procedure for evaluating regional nodal status in early breast cancer, achieving a high detection rate and low recurrence rate. This technique allows for the omission of axillary dissection in approximately 70% of cases.

Area of Science:

  • Oncology
  • Surgical Pathology

Context:

  • Sentinel node biopsy is a crucial staging procedure for early breast cancer.
  • Accurate assessment of regional nodal status impacts treatment decisions and patient outcomes.

Purpose:

  • To evaluate the daily practice and outcomes of 1000 consecutive sentinel node (SN) biopsies in breast cancer patients.
  • To analyze technical aspects, pathological findings, and treatment implications of SN biopsy.

Summary:

  • A prospective review of 1000 SN biopsies demonstrated a high detection rate (98.7%).
  • Factors like patient age, tumor size, and detection method influenced SN positivity.
  • Axillary dissection was performed in 16% immediately and 12% delayed.
  • Of 923 invasive/micro-invasive carcinomas with detected SN, 30.5% were positive; 34% of these had positive non-sentinel nodes.

Related Experiment Videos

  • Recurrence rates were low (0.1-8.3%), with higher rates observed in cases with macrometastases or micrometastases without axillary dissection.
  • Impact:

    • Sentinel node biopsy is a reliable procedure for staging early breast cancer, enabling the omission of axillary dissection in up to 70% of patients.
    • This approach optimizes treatment by accurately identifying nodal involvement while minimizing surgical morbidity.