[Spondylodiskitis caused by Candida albicans. Report of two new cases]

Area of Science:

• Medical Mycology
• Infectious Diseases
• Spinal Infections

Background:

• Candidiasis infections are increasing, linked to factors like immunodepression, catheters, and prolonged antibiotic therapy.
• Spondylodiskitis, an infection of the spine and intervertebral discs, is rarely caused by Candida species.
• Intravenous drug use (IDU) and Human Immunodeficiency Virus (HIV) infection are associated risk factors for invasive candidiasis.

Observation:

• Two cases of spondylodiskitis caused by Candida albicans are presented.
• Both patients were identified as intravenous drug users (IDUs) with a history of HIV infection.
• Common symptoms included pain, fever, and a general constitutional syndrome.

Findings:

• Candida albicans spondylodiskitis is a rare but serious complication in immunocompromised individuals, particularly those with HIV and a history of IDU.
• Clinical presentation often involves significant pain, fever, and constitutional symptoms.
• Diagnosis requires a high index of suspicion and appropriate microbiological and imaging studies.

Implications:

• Increased awareness of rare fungal infections like Candida spondylodiskitis is crucial for timely diagnosis and treatment.
• Understanding the risk factors, such as HIV and IDU, can guide preventative strategies and early intervention.
• Effective management involves a multidisciplinary approach, combining antifungal therapy with surgical or conservative measures as indicated.