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Updated: Aug 18, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Exhaustively methylated azacalix[4]arene: preparation, conformation, and crystal structure with exclusively
Hirohito Tsue1, Koichi Ishibashi, Hiroki Takahashi
1Graduate School of Global Environmental Studies, Kyoto University, Kyoto 606-8501, Japan. tsue@ger.mbox.media.kyoto-u.ac.jp
Abstract:
[structure: see text]. Described are the preparation, conformation, and crystal structure of exhaustively methylated azacalix[4]arene involving nitrogen atoms as bridging units. NMR and X-ray crystallographic analysis have demonstrated that this novel azacalix[4]arene adopts a 1,3-alternate conformation both in solution and in the solid state. The crystal structure has been characterized solely by intermolecular CH/pi interactions, by which the azacalix[4]arenes mutually interact with each other outside the cavity to furnish a two-dimensional network structure.
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