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[Effects of Accupro on structural and hemodynamic changes in patients with chronic heart failure]

G Tabidze1, M Iakobashvili, N Kobaladze

  • 1Insitute of Cardiology, Tbilisi, Georgia.

Georgian Medical News
|May 24, 2005
PubMed

Insights

Accupro effectively treats chronic heart failure by improving cardiac function and reducing vascular resistance. This study shows positive effects on left ventricular dimensions and ejection fraction in patients with heart failure.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Angiotensin converting-enzyme inhibitors (ACE inhibitors) are established treatments for chronic heart failure.
  • Their efficacy is primarily attributed to reducing afterload by inhibiting angiotensin II formation.

Purpose of the Study:

  • To evaluate the effectiveness of Accupro on structural and hemodynamic parameters in patients diagnosed with heart failure.
  • To assess the impact of Accupro on cardiac function and vascular resistance.

Main Methods:

  • A study involving 37 patients (aged 61-84) with postinfarction cardiosclerosis and mild to moderate hypertension, experiencing Class I-III heart failure.
  • Patients received Accupro (13.7+/-0.97 mg/day) for 3 months, combined with furosemide (40-80 mg, 1-3 times/week).

Main Results:

  • Accupro treatment, alongside diuretics, positively impacted left ventricular dimensions and increased left ventricular ejection fraction and cardiac index.
  • Left ventricular diastolic function improved in over two-thirds of patients.
  • A reduction in total peripheral resistance was observed, correlating with improved cardiac structure and function.

Conclusions:

  • Accupro demonstrates beneficial effects in managing chronic heart failure.
  • The drug contributes to the improvement of structural-functional cardiac status and hemodynamics in heart failure patients.

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