Related Experiment Video
Updated: Aug 17, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
The ventilator circuit and ventilator-associated pneumonia
1Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0558, USA. richard.branson@.uc.edu
Abstract:
Historically, the relationship between the ventilator circuit and pulmonary infection was accepted as fact, without any scientific evidence. Hence the term, "ventilator"-associated pneumonia. Recent evidence, however, has demonstrated that the major sources of pneumonia in the ventilated patient are colonization of the gastrointestinal tract, with subsequent aspiration around the endotracheal tube cuff, and contamination by caregivers. In recent years, the relationship of respiratory care equipment to ventilator-associated pneumonia has been studied carefully. A number of clinical trials have demonstrated that routine changing of the ventilator circuit fails to impact the incidence of pneumonia in the ventilated patient. Additional studies evaluating the type of humidification device, type of suctioning device, and frequency of change of the devices have resulted in conflicting evidence. This paper reviews the role of the humidifier, ventilator circuit, and airway suctioning equipment on the pathogenesis and prevention of ventilator-associated pneumonia.
Insights
Routine ventilator circuit changes do not prevent ventilator-associated pneumonia (VAP). New evidence suggests gastrointestinal colonization and caregiver contamination are primary VAP sources, not respiratory equipment.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Respiratory Therapy
Background:
- Historically, ventilator circuits were presumed to cause ventilator-associated pneumonia (VAP).
- Recent evidence implicates gastrointestinal colonization and caregiver contamination as primary VAP sources.
- The role of respiratory care equipment in VAP pathogenesis requires re-evaluation.
Purpose of the Study:
- To review the scientific evidence regarding the role of respiratory care equipment in VAP.
- To examine the impact of ventilator circuit changes on VAP incidence.
- To discuss the influence of humidification and suctioning devices on VAP prevention.
Main Methods:
- Review of clinical trials and scientific literature on VAP.
- Analysis of studies evaluating ventilator circuit change frequency.
- Examination of research on humidification and suctioning devices in VAP.
Main Results:
- Routine ventilator circuit changes do not reduce VAP incidence.
- Evidence on the impact of different humidification and suctioning devices is conflicting.
- Gastrointestinal colonization and caregiver contamination are identified as major VAP contributors.
Conclusions:
- The link between ventilator circuits and VAP is not supported by current evidence.
- Focus should shift from routine circuit changes to other VAP prevention strategies.
- Further research is needed to clarify the role of specific respiratory equipment in VAP.
More Related Videos
Related Concept Videos
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation I: Indication and Settings
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
