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Related Experiment Videos

Expression profiling the human septin gene family.

Peter A Hall1, Kenneth Jung, Kenneth J Hillan

  • 1Centre for Cancer Research and Cell Biology, Queen's University Belfast, University Floor, Tower Block, Belfast City Hospital, Belfast BT9 7AB, UK. peter.hall@qub.ac.uk

The Journal of Pathology
|May 26, 2005
PubMed
Summary

This study comprehensively catalogs septin gene expression across diverse tissues, identifying a new septin (SEPT13) and revealing widespread alterations in disease, particularly in the central nervous system (CNS). These findings enhance understanding of septin roles in health and disease.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Septins are conserved GTP-binding proteins crucial for cellular functions like vesicle trafficking and cytoskeleton remodeling.
  • Dysregulation of septins is implicated in various diseases, including neurodegeneration and cancer.

Purpose of the Study:

  • To conduct a comprehensive analysis of human septin gene expression in normal, diseased, and tumor tissues.
  • To identify novel septins and characterize the expression patterns of known septins and their isoforms.

Main Methods:

  • DNA microarray analysis of 10,360 tissue samples.
  • Bioinformatic analysis of gene expression data to identify expression patterns and isoforms.

Main Results:

Related Experiment Videos

  • A novel septin, SEPT13, was identified and found to be related to SEPT7.
  • All 13 human septins are expressed ubiquitously, with specific isoforms showing tissue-specific enrichment (e.g., lymphoid and brain tissues).
  • Septin expression perturbations were widespread in various diseases, with significant alterations observed in all 13 septin genes in central nervous system (CNS) conditions.

    • Conclusions:

    • This study provides a comprehensive catalog of septin gene expression in health and disease.
    • Understanding septin expression complexity is vital for elucidating their roles in physiological and pathological processes.
    • Alterations in septin gene expression are prominent in CNS diseases, highlighting their potential as biomarkers or therapeutic targets.