Fully injectable calcium phosphate cement--a promise to dentistry

Area of Science:

• Biomaterials Science
• Dental Materials Science
• Regenerative Medicine

Background:

• Calcium phosphate cements (CPC) are biocompatible bone substitutes with potential in dentistry.
• Poor rheological properties of traditional CPCs limit their clinical application.
• A novel formulation, fully injectable calcium phosphate cement (FI-CPC), has been developed.

Purpose of the Study:

• To investigate the suitability of FI-CPC for dental applications.
• To evaluate the cementing, material, rheological, and biocompatibility properties of FI-CPC.
• To assess FI-CPC's potential for endodontic and periodontic uses.

Main Methods:

• Material characteristics testing for cementing and rheological properties.
• Biocompatibility evaluation according to ISO 7405 standards.
• Assessment of setting time, compressive strength, dimensional stability, injectability, and cohesion.

Main Results:

• FI-CPC exhibits a 20-minute setting time and >11 MPa compressive strength, meeting clinical requirements.
• The cement sets without exothermic reaction, shows good dimensional stability, and is easily injectable through an 18-gauge needle.
• FI-CPC demonstrates excellent cohesion in water, sets into a hydroxyapatite mass, adheres well to dentin, and is non-toxic, non-allergic, non-pyrogenic, and soft-tissue compatible.

Conclusions:

• FI-CPC is a self-setting, biocompatible paste with superior rheological properties for surgical dental applications.
• The set cement provides effective and stable sealing, with osteoconductive properties being an advantage.
• FI-CPC is an ideal material for endodontic sealing/filling and periodontic repair.