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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Contrast nephropathy post cardiac resynchronization therapy: an under-recognized complication with important

Peter J Cowburn1, Harshna Patel, Rebecca R Pipes

  • 1Mount Sinai Hospital, 600 University Avenue, Suite 1609, Toronto, Ontario, Canada, M5G 1X5.

European Journal of Heart Failure
|May 28, 2005
PubMed

Insights

Contrast nephropathy, a kidney complication, affects 14% of patients after cardiac resynchronization therapy (CRT). This under-recognized risk increases morbidity, mortality, and hospital stays, requiring greater patient and physician awareness.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Complications

Background:

  • Cardiac resynchronization therapy (CRT) is an advanced treatment for heart failure.
  • CRT procedures are technically complex and carry inherent risks.
  • Contrast nephropathy is a known complication of angiography but not previously described after CRT.

Purpose of the Study:

  • To determine the incidence of contrast nephropathy in patients undergoing CRT.
  • To identify risk factors and outcomes associated with contrast nephropathy post-CRT.

Main Methods:

  • Retrospective chart review of patients who underwent CRT at a tertiary referral center.
  • Contrast nephropathy defined as a ≥25% increase in serum creatinine within 48 hours of contrast administration.

Main Results:

  • 14% (10 of 68 patients) developed contrast nephropathy.
  • Pre-existing elevated creatinine (≥200 µmol/L) was associated with higher risk (43% vs. 7%).
  • Contrast nephropathy led to significantly longer hospital stays (19 days vs. 4 days).

Conclusions:

  • Contrast nephropathy is a frequent and under-recognized complication of CRT.
  • This complication is associated with significant morbidity, mortality, and increased healthcare costs.
  • Increased awareness among patients and physicians regarding this risk is crucial.
Abstract

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