Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The REALAB project: a new method for the formulation of reference intervals based on current data.

Enzo Grossi1, Roberto Colombo, Silvio Cavuto

  • 1Research & Development, Centro Diagnostico Italiano, Milan, Italy.

Clinical Chemistry
|May 28, 2005
PubMed
Summary

Establishing accurate reference intervals is crucial for primary healthcare wellness monitoring. This study developed sex- and age-specific reference limits for 23 basic laboratory tests using a large dataset and nonparametric methods.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-based autism identification from hyperspectral imaging detection of oxidative stress in pediatric red blood cells.

Communications medicine·2026
Same author

Feasibility of an early versus delayed rehabilitation intervention in patients with lung cancer on cancer-related fatigue: a pilot RCT.

Future oncology (London, England)·2026
Same author

Ocular diagnostics and occipital neurovascular coupling in ocular hypertension and open angle glaucoma.

Frontiers in neuroscience·2025
Same author

Initial steps toward the first Compassionate Community in Italy: A study protocol.

Palliative care and social practice·2025
Same author

From patient voices to optimal PROMs: a mixed methods framework for cancer survivorship care.

Journal of cancer survivorship : research and practice·2025
Same author

Relationship Between Vision and Postural Control in Children With Autism Spectrum Disorder: Is It Time to Move Forward? A Scoping Review.

Motor control·2025

Area of Science:

  • Clinical Laboratory Science
  • Biostatistics
  • Primary Healthcare

Background:

  • Primary healthcare centers focus on wellness and require accurate patient data comparison.
  • Establishing appropriate reference intervals is vital for effective patient management and health maintenance.

Purpose of the Study:

  • To derive robust, institution-specific reference intervals for common laboratory tests.
  • To support wellness monitoring and accurate interpretation of patient results in a primary care setting.

Main Methods:

  • Retrieved approximately 15 million laboratory records from 197,350 individuals over 3 years.
  • Applied inclusion/exclusion criteria, including basic tests, single measurements, and absence of correlated abnormalities.
  • Utilized a novel multivariate algorithm and Spearman correlation matrix for data analysis, followed by nonparametric percentile estimation.

Related Experiment Videos

Main Results:

  • Reduced the initial sample to 61,246 individuals for the reference sample group.
  • Calculated sex-specific and age-related reference limits for 23 basic tests and 13 additional quantities.
  • Demonstrated the utility of nonparametric estimation for deriving reliable reference limits.

Conclusions:

  • Reference values derived from large, institution-specific datasets are highly suitable for evaluating patient results.
  • This method enhances the accuracy of health assessments in primary care settings.
  • The derived reference intervals can improve the quality of wellness monitoring.