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Related Experiment Videos

Down syndrome screening in twins.

Melissa C Bush1, Fergal D Malone

  • 1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine, 101 The City Drive, Orange, CA 92868, USA. melissacbush@hotmail.com

Clinics in Perinatology
|June 1, 2005
PubMed
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Screening for Down syndrome (DS) in twin pregnancies has several options, but detection rates are lower than in singletons. Nuchal translucency screening offers improved detection for twin DS screening.

Area of Science:

  • Maternal-Fetal Medicine
  • Prenatal Diagnostics
  • Genetics

Background:

  • Down syndrome (DS) screening in twin gestations presents unique challenges compared to singleton pregnancies.
  • Existing screening methods for twin pregnancies have varying detection rates and complexities.

Purpose of the Study:

  • To review available screening methods for Down syndrome in twin gestations.
  • To discuss the detection rates and limitations of current screening protocols for twin pregnancies.
  • To inform patients about diagnostic options following positive screening results.

Main Methods:

  • Review of existing literature on Down syndrome screening in twin pregnancies.
  • Analysis of detection rates and false-positive rates for various screening modalities.

Related Experiment Videos

  • Consideration of combined screening approaches across different gestational ages.

    • Main Results:

    • Biochemical screening in twin gestations shows at least a 15% lower detection rate than in singleton pregnancies.
    • Nuchal translucency measurement can improve DS detection in twins, with modeling data suggesting 75%–85% detection rates.
    • A 5% false-positive rate is associated with current screening methods for DS in twin pregnancies.

    Conclusions:

    • Current Down syndrome screening methods for twin pregnancies have limitations in detection rates compared to singletons.
    • Nuchal translucency screening shows promise for improving DS detection in twins.
    • Patients undergoing screening must be informed of all diagnostic and management options for fetal aneuploidy.