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Updated: Aug 17, 2026

A Method For Production of Recombinant mCD1d Protein in Insect Cells.
Published on: December 10, 2007
Development and function of CD1d-restricted NKT cells: influence of sphingolipids, SAP and sex
Johan K Sandberg1, Hans-Gustaf Ljunggren
1Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden. Johan.Sandberg@medhs.ki.se
Abstract:
Natural killer T (NKT) cells are innate-like lymphocytes with immunoregulatory properties. They express an invariant and conserved T-cell receptor that recognizes glycolipids presented by CD1d. Manipulation, activation or loss of NKT cells has profound effects on diverse immune functions and can influence desirable responses to infectious organisms and tumors, as well as undesirable responses to autoantigens. Here, we discuss recent progress in the identification of natural endogenous and exogenous CD1d-presented antigens, the understanding of factors that regulate development of NKT cells in the thymus and of factors that influence their function in the periphery. Clinical implications of these findings are briefly touched on.
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