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Updated: Aug 17, 2026
09:04
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Total synthesis of nigellicine and nigeglanine hydrobromide
Eric L Elliott1, Simon M Bushell, Marta Cavero
1E. F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.
Organic Letters
|June 4, 2005
Abstract:
[reaction: see text] The first syntheses of the pyridazinoindazolium alkaloids nigellicine and nigeglanine hydrobromide via a common intermediate are described. Ortho-lithiation/acylation and the direct amination of an isatin ring system are the key steps in the synthesis.
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