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Desmoid tumors and deep fibromatoses
1Medical Clinic and Polyclinic III, Clinic Grosshadern Munich, Ludwig-Maximilian-University Munich, Marchioninistrasse 15, Muenchen D-81377, Germany. Marcus.Schlemmer@med.uni-muenchen.de
Hematology/Oncology Clinics of North America
|June 9, 2005
Summary
Desmoid tumors, or deep fibromatoses, are rare benign growths that can invade locally and recur. While not cancerous, they can cause serious illness and require surgical treatment, with other therapies available if surgery isn't possible.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Desmoid tumors (deep fibromatoses) are rare, benign neoplasms.
- They are associated with pregnancy and Gardner syndrome.
- Characterized by fibroblasts, they invade locally and recur frequently.
Purpose of the Study:
- To review the biology and clinical features of desmoid tumors.
- To discuss their pathology, including local invasion and recurrence.
- To outline current treatment strategies.
Main Methods:
- Literature review of desmoid tumor biology and clinical presentation.
- Analysis of pathological characteristics and behavior.
- Summary of treatment modalities including surgery, radiation, and systemic therapy.
Main Results:
- Desmoid tumors exhibit bland fibroblasts and indistinct margins.
- They can cause significant morbidity and mortality via local invasion.
- Different locations (abdomen, extremities) show varied biologic behavior.
Conclusions:
- Desmoid tumors are locally aggressive benign neoplasms, not true cancers.
- Surgical intervention is the primary treatment.
- Radiation and systemic therapies offer alternatives when surgery is not feasible.