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Optical biosensor with dispersion compensation.

W Zong1, C Thirstrup, M H Sørensen

  • 1Vir Biosensor, Vir A/S, Kuldyssen 10, DK-2630 Taastrup, Denmark.

Optics Letters
|June 10, 2005
PubMed
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This study presents a novel method to compensate for wavelength dispersion in surface plasmon resonance (SPR) biosensors using diffractive optical elements. This enhances biosensor robustness and performance across the entire dynamic measurement range.

Area of Science:

  • Optical Engineering
  • Biomedical Sensing
  • Materials Science

Background:

  • Wavelength dispersion limits performance in optical systems, including surface plasmon resonance (SPR) biosensors.
  • In SPR biosensors, dispersion is influenced by the effective refractive index of biochemical analytes.
  • Existing SPR systems can be sensitive to wavelength fluctuations.

Purpose of the Study:

  • To develop and demonstrate a method for compensating wavelength dispersion in SPR biosensors.
  • To improve the robustness and performance of SPR biosensors against wavelength variations.
  • To present a versatile concept applicable to other refractive-index-based sensors.

Main Methods:

  • Integration of two diffractive optical coupling elements within a polymer substrate.

Related Experiment Videos

  • Utilizing these elements to actively compensate for wavelength dispersion.
  • Characterization of the dispersion-compensated SPR biosensor performance.

    • Main Results:

    • Successful compensation of wavelength dispersion across the entire dynamic measurement range.
    • Demonstration of enhanced robustness to wavelength fluctuations compared to prism-coupler SPR systems.
    • Validation of the diffractive optical element approach for dispersion management.

    Conclusions:

    • The proposed method effectively compensates for wavelength dispersion in SPR biosensors.
    • The diffractive optical coupling element approach offers superior robustness and performance.
    • This dispersion compensation strategy is adaptable for various refractive-index sensing applications.