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The challenge of mild persistent asthma
1Department of Pediatrics and Internal Medicine, Virginia Commonwealth University Health Systems, Richmond, Virginia 23298, USA. airani@vcu.edu
Summary
Current data suggest asthma severity is established early in life, with limited options to reverse airway changes. The primary goal for mild persistent asthma is preventing exacerbations, not halting progression.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Pediatric Respiratory Medicine
Background:
- Asthma is a chronic respiratory condition affecting millions worldwide.
- Understanding asthma severity and progression is crucial for effective management.
- Mild persistent asthma presents unique challenges in treatment guidelines.
Purpose of the Study:
- To review current data on mild persistent asthma.
- To evaluate available treatment options for mild persistent asthma.
- To clarify therapeutic goals for mild persistent asthma.
Main Methods:
- Comprehensive MEDLINE literature search.
- Inclusion of relevant articles based on expert opinion.
- Review of current evidence on asthma progression and treatment.
Main Results:
- Asthma severity is often determined in early childhood.
- No current therapy effectively prevents or reverses airway remodeling in persistent asthma.
- Focus on exacerbation prevention is key for patients beyond early childhood.
Conclusions:
- Unlike moderate/severe asthma, clear guidelines for mild persistent asthma are lacking.
- Inhaled corticosteroids are standard for moderate/severe asthma.
- Mild asthma without severe exacerbations may require minimal intervention.