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Related Experiment Videos

First example of Rh:-32,-46 red cell phenotype.

J R Storry1, M Gorman, N I Maddox

  • 1National Reference Laboratoy for Blood Group Serology, American Red Cross Blood Services, 15601 Crabbs Branch Way, Rockville, MD 20855, USA.

Immunohematology
|December 1, 1994
PubMed
Summary

This study identifies a novel red blood cell (RBC) phenotype, Rh:-32,-46, in a white male donor. This finding is significant as it

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Area of Science:

  • Immunology
  • Genetics
  • Hematology

Background:

  • The Rh blood group system is complex, with numerous antigens and phenotypes.
  • Rare Rh phenotypes, such as Rhnull and deletion types, are clinically significant.
  • The Rh46 antigen has been previously associated with deletion types or Rh:32.

Purpose of the Study:

  • To characterize a novel red blood cell (RBC) phenotype, Rh:-32,-46.
  • To investigate the serological properties of the alloantibody found in the donor's serum.
  • To compare this finding with previously described Rh:-46 RBCs.

Main Methods:

  • Standard blood group typing techniques were employed.
  • Serological testing included reactivity with various RBCs and enzyme/chemical treatments (ficin, papain, AET, DTT).

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  • Phenotyping of multitransfused patients was also assessed.

    • Main Results:

    • A white male donor presented with a rare Rh:-32,-46 RBC phenotype, not associated with known Rh deletion or Rhnull types.
    • The donor's serum contained an alloantibody reactive with most RBCs, except Rhnull and D-- types.
    • Reactivity was enhanced by ficin/papain treatment and unaffected by AET/DTT.

    Conclusions:

    • This is the first report of an Rh:-32,-46 phenotype not linked to rare Rh deletion or Rhnull types.
    • The findings expand the understanding of Rh antigen diversity and alloantibody formation.
    • The rare Rh:w5,w19,-31,-34 phenotype observed in the donor is also noteworthy in Caucasian populations.