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Updated: Aug 9, 2026

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
Published on: May 21, 2010
Cerebellar abnormalities on proton MR spectroscopy in gluten ataxia
I D Wilkinson1, M Hadjivassiliou, J M Dickson
1Academic Unit of Radiology, University of Sheffield, Sheffield, England. i.d.wilkinson@shef.ac.uk
Abstract:
Gluten sensitivity can manifest with ataxia. The metabolic status of the cerebellum was investigated in 15 patients with gluten ataxia and 10 controls using proton MR spectroscopy. Significant differences were present in mean N-acetyl aspartate levels at short echo time and N-acetyl aspartate/choline ratios at long echo time between the patient and control groups. These data support the hypothesis that cerebellar neuronal physiology differs between patients with gluten ataxia and healthy controls.
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