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Incidence of inducible clindamycin resistance in staphylococci: first results from Turkey

O K Azap1, H Arslan, F Timurkaynak

  • 1Baskent University Faculty of Medicine, Infectious Disease and Clinical Microbiology, Ankara, Turkey. okurtazap@baskent-ank.edu.tr

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|June 22, 2005
PubMed

Insights

Inducible clindamycin resistance (ICR) was detected in Staphylococcus isolates using the D-test. Methicillin-resistant coagulase-negative staphylococci showed the highest ICR rates, highlighting the need for local D-test evaluation.

Area of Science:

  • Microbiology
  • Antimicrobial Resistance

Background:

  • Antibiotic resistance in Staphylococcus species is a growing public health concern.
  • Accurate detection of inducible clindamycin resistance (ICR) is crucial for effective treatment of staphylococcal infections.

Purpose of the Study:

  • To determine the prevalence of inducible clindamycin resistance (ICR) in various Staphylococcus isolates.
  • To evaluate the efficacy of the disk-diffusion induction test (D-test) for detecting ICR.

Main Methods:

  • Tested 408 staphylococcal isolates (MRSA, MSSA, MR-CoNS, MS-CoNS) for ICR using the D-test.
  • Utilized erythromycin or azithromycin disks in conjunction with clindamycin disks.

Main Results:

  • ICR was detected in 5.7% of MRSA, 3.6% of MSSA, 30.8% of MR-CoNS, and 11.2% of MS-CoNS isolates.
  • All erythromycin-resistant, clindamycin-susceptible MRSA isolates were positive by D-test.
  • All isolates remained susceptible to quinupristin-dalfopristin.

Conclusions:

  • Methicillin-resistant coagulase-negative staphylococci exhibited the highest rates of inducible clindamycin resistance.
  • The D-test is effective in identifying ICR in Staphylococcus isolates.
  • Local evaluation of the D-test's cost-benefit is recommended based on observed resistance phenotypes.

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