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[Reactive arthritis due to Clostridium difficile].

S Ducroix-Roubertou¹, C Genet, J P Rogez

¹Service des maladies infectieuses et tropicales, CHU Dupuytren, 2, 87042 Limoges cedex, France.

Medecine Et Maladies Infectieuses

|June 29, 2005

Summary

Clostridium difficile infection can rarely cause reactive arthritis. This case highlights Fiessinger-Leroy-Reiter syndrome following C. difficile colitis, successfully treated with NSAIDs.

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Area of Science:

Rheumatology
Infectious Diseases

Background:

Extracolonic manifestations of Clostridium difficile infection are uncommon.
Reactive arthritis is a rare complication of C. difficile infections.

Observation:

A 45-year-old man presented with fever and monoarthritis of the left knee.
Symptoms began 8 days after C. difficile enterocolitis and urethritis.
Diagnostic workup, including cultures and bone scintigraphy, was performed.

Findings:

The patient was diagnosed with Fiessinger-Leroy-Reiter syndrome based on arthritis and urethritis.
Antibiotics for arthritis were ineffective, but NSAIDs led to rapid symptom resolution.
The patient recovered fully within 48 hours with no relapse at four months.

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Implications:

This case underscores the importance of considering C. difficile infection as a potential trigger for reactive arthritis.
Fiessinger-Leroy-Reiter syndrome can manifest following C. difficile-associated colitis.
Non-steroidal anti-inflammatory drugs (NSAIDs) may be effective in managing this specific presentation.