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Related Experiment Videos

Multiple myeloma with scleroderma-like changes.

C Paredes-Suárez1, V Fernández-Redondo, M Vázquez Blanco

  • 1Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, 15782 Santiago de Compostela, Spain. mejaime@usc.es

Journal of the European Academy of Dermatology and Venereology : JEADV
|July 1, 2005
PubMed
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A patient with multiple myeloma experienced generalized itching, skin hardening, and kidney failure. These symptoms, resembling scleroderma, were linked to the underlying cancer.

Area of Science:

  • Dermatology
  • Nephrology
  • Oncology

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Scleroderma is an autoimmune connective tissue disease characterized by skin hardening.

Observation:

  • A patient presented with generalized pruritus, brownish sclerodermatous plaques, and sclerodactyly.
  • Laboratory tests revealed a monoclonal band for IgG-kappa.

Findings:

  • Bone marrow examination confirmed multiple myeloma.
  • The patient rapidly developed anuric renal failure and malignant hypertension.
  • Skin sclerosis was observed, mimicking systemic scleroderma.

Implications:

  • This case highlights the association between multiple myeloma and scleroderma-like skin changes.

Related Experiment Videos

  • Differentiating these neoplastic-related skin manifestations from systemic scleroderma is crucial for accurate diagnosis and treatment.
  • Early recognition of these cutaneous signs may aid in the diagnosis of underlying plasma cell dyscrasias.