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Updated: Aug 17, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Early administration of hyperbaric oxygen therapy in distraction osteogenesis--a quantitative study in New Zealand
I-Chun Wang1, Steve Wen-Neng Ueng, Li-Jen Yuan
1Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taiwan.
Background:
We investigated the effect of hyperbaric oxygen (HBO) therapy on the early phase of tibial lengthening in our established rabbit model.
Methods:
Twenty-four male rabbits (six per group) underwent right tibial lengthening by 5 mm. Group 1 then underwent 2.5 atmospheres of absolute hyperbaric oxygenation for 2 hours daily for 6 weeks postoperatively; group 2, for early 5 weeks (weeks 1-5), group 3, for late 5 weeks (weeks 2-6), and group 4 had no HBO therapy. Bone mineral density (BMD) was measured before surgery and weekly thereafter from weeks 2 through 6. The mechanical strengths of the lengthened tibias were measured.
Results:
Significantly higher mean %BMDs were obtained for groups 1 and 2 compared with groups 3 and 4. There was no difference in the mean %BMD between groups 1 and 2 (p > 0.05). The results were similar for mean percentage maximal torque; group 1 had the maximum torque, followed sequentially by groups 2 though 4.
Conclusion:
The study results suggest that early and full-term administration of HBO therapy on tibial lengthening may achieve better benefits.
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