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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Inverted nasosinusal papilloma. 11 cases and bibliographic revision]
D Alonso Párraga1, A Clemente García, D Sánchez Ruiz
1Sección Rinológía, Servicio ORL, Complejo H. Universitario Xeral-Cíes.
Summary
Endoscopic polipectomy with microdebrider (PEM) is effective for inverted papilloma type 1. This minimally invasive technique avoids malignant transformation and offers good follow-up results.
Area of Science:
- Otolaryngology
- Rhinology
- Oncology
Background:
- Review of inverted papilloma (IP) cases diagnosed between 1998 and 2003.
- Bibliography revision on IP etiology, symptoms, and surgical techniques.
Purpose of the Study:
- To evaluate the efficacy of endoscopic polipectomy with microdebrider (PEM) for inverted papilloma type 1.
- To assess the outcomes and recurrence rates of PEM in IP treatment.
Main Methods:
- Retrospective analysis of 11 patients (40-79 years old) with inverted papilloma type 1.
- Diagnosis via endoscopy and biopsy.
- Surgical exeresis using endoscopic polipectomy with microdebrider (PEM).
- Surgical approaches included endoscopic (CEN), mixed endonasal, canine fossa, nasal, and Caldwell-Luc.
Main Results:
- All 11 cases were classified as Krouse stages I, II, and III.
- Follow-up ranged from 9 to 64 months.
- One recurrence was observed and treated with open surgery.
- No malignant transformations were noted.
Conclusions:
- Endoscopic polipectomy with microdebrider (PEM) is a viable and effective treatment for inverted papilloma type 1.
- The study proposes tumor staging and performing PEM with topical anesthesia and deep biopsies for unilateral poly formations to ensure early diagnosis and facilitate endoscopic techniques.

