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[Tocolysis with nifedipine: its use in current practice]
Y Bekkari1, J Lucas, T Beillat
1Service de gynécologie-obstétrique et médecine de la reproduction, CHRU Georges-Clemenceau, boulevard Georges-Clemenceau, 14033 Caen cedex, France.
Objectives:
To assess tocolysis with nifedipine in preterm labour during actual clinical practice in terms of efficacy and safety.
Patients And Methods:
Retrospective observational study during two years including preterm labour between 26 and 33+6 weeks of amenorrhea. Preterm labour was defined by the presence of three or more uterine contractions in 10 minutes associated to cervical modifications diagnosed by vaginal sonography (length
Results:
Fifty-eight patients were included, 10 of whom having a twin pregnancy. Success was obtained in 84% of patients (49/58). All of these women did not deliver during the first seven days after introduction of tocolysis. Five patients delivered in the first two days after tocolysis and four others required a change in tocolysis. Mean gestational age at delivery was 37+5 weeks and 35 weeks for single and twin pregnancies, respectively. No maternal or fetal side effects were described.
Discussion And Conclusion:
Nifedipine could be prescribed for tocolysis in actual clinical practice because it seems to have safety and excellent tolerance.
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