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Related Experiment Videos

[Tocolysis with nifedipine: its use in current practice].

Y Bekkari1, J Lucas, T Beillat

  • 1Service de gynécologie-obstétrique et médecine de la reproduction, CHRU Georges-Clemenceau, boulevard Georges-Clemenceau, 14033 Caen cedex, France.

Gynecologie, Obstetrique & Fertilite
|July 12, 2005
PubMed
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Nifedipine effectively manages preterm labor, delaying delivery in 84% of cases with excellent safety and tolerance. This study confirms its utility in clinical practice for pregnant individuals experiencing preterm labor.

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Maternal-Fetal Medicine

Context:

  • Preterm labor presents significant risks to both mother and neonate.
  • Effective tocolysis is crucial for improving perinatal outcomes.
  • Nifedipine is a commonly used tocolytic agent, but its real-world efficacy and safety require ongoing assessment.

Purpose:

  • To evaluate the efficacy and safety of nifedipine for tocolysis in preterm labor within a clinical setting.
  • To determine the success rate of nifedipine in delaying delivery beyond 48 hours.
  • To assess maternal and fetal outcomes associated with nifedipine tocolysis.

Summary:

  • This retrospective observational study included 58 patients with preterm labor (26-33+6 weeks).
  • Nifedipine tocolysis (30 mg oral) resulted in successful delay of delivery in 84% (49/58) of patients.

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  • Mean gestational age at delivery was 37+5 weeks for singletons and 35 weeks for twins, with no reported maternal or fetal side effects.

    • Impact:

    • Nifedipine demonstrates significant efficacy in delaying delivery for preterm labor.
    • The drug exhibits a favorable safety profile, with no adverse maternal or fetal events observed.
    • Findings support the continued use of nifedipine as a safe and effective tocolytic agent in clinical practice.