[Acceptability of continuous combined versus cyclical HRT: a French multicentric randomized clinical study]

Area of Science:

• Gynecology
• Endocrinology
• Menopause Research

Background:

• Hormone replacement therapy (HRT) is used for menopausal symptoms.
• Sequential estroprogestative HRT can cause side effects leading to treatment switches.
• Continuous combined HRT options like Climodiène and cyclic HRT like Climène offer alternatives.

Purpose of the Study:

• To compare the acceptability and quality of life (QoL) of two HRT regimens over 12 cycles.
• To evaluate Climodiène (continuous combined) versus Climène (cyclic) in postmenopausal women switching from sequential HRT due to side effects.

Main Methods:

• A randomized study involving 143 postmenopausal women.
• Participants received either Climodiène or Climène for 12 cycles.
• Acceptability assessed by continuation rates; QoL measured using the Women's Health Questionnaire (WHQ) and a satisfaction questionnaire.

Main Results:

• Both Climène and Climodiène significantly improved overall WHQ scores after 12 months.
• Climodiène showed a trend towards greater QoL improvement, especially for hot flushes.
• Climodiène use was associated with significant reductions in sleep problems and cognitive function issues.

Conclusions:

• Both HRT regimens are effective in improving QoL for postmenopausal women.
• Climodiène demonstrates clinically relevant benefits in reducing sleep disturbances and cognitive issues.
• This study provides valuable prospective data on Climodiène's impact on QoL in postmenopausal women.