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Aspergillus terreus endophthalmitis.

Jay C Bradley1, Joel G George, Juan C Sarria

  • 1Department of Ophthalmology and Visual Sciences, Texas Tech University, Health Sciences Center, Lubbock, Texas, USA. docjayb@aol.com

Scandinavian Journal of Infectious Diseases
|July 14, 2005
PubMed
Summary
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Aspergillus terreus endophthalmitis is a rare but serious eye infection. Early suspicion is key, as this fungus is often resistant to standard treatments, leading to poor outcomes.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Mycology

Background:

  • Endophthalmitis is a severe intraocular inflammation, often sight-threatening.
  • Fungal endophthalmitis, particularly from Aspergillus species, presents diagnostic and therapeutic challenges.

Observation:

  • A case of Aspergillus terreus endophthalmitis is presented.
  • A review of four previously reported cases of Aspergillus terreus endophthalmitis was conducted.

Findings:

  • Aspergillus terreus endophthalmitis requires high clinical suspicion in patients with risk factors.
  • Risk factors include immunosuppression, intravenous drug use, and intraocular surgery or trauma.
  • Aspergillus terreus frequently demonstrates resistance to amphotericin B, a common antifungal agent.

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Implications:

  • Prompt diagnosis and appropriate antifungal therapy are crucial for managing Aspergillus terreus endophthalmitis.
  • Treatment strategies may need to consider antifungal resistance patterns.
  • Poor visual outcomes are common despite current therapeutic interventions.