Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperparathyroidism accompanying multiple myeloma.

Nick Patel1, Arunabh Talwar, Laura Donahue

  • 1Department of Medicine, North Shore University Hospital, Manhasset, New York 11030, USA.

Clinical Nuclear Medicine
|July 19, 2005
PubMed
Summary

Persistent hypercalcemia after multiple myeloma treatment can indicate a coexisting parathyroid adenoma. Surgical removal of the benign parathyroid adenoma resolved the hypercalcemia in this rare case.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter: Role of spirometry in fixed upper airway obstruction.

Cleveland Clinic journal of medicine·2026
Same author

Mirvetuximab soravtansine plus pembrolizumab in recurrent folate receptor alpha-positive uterine serous carcinoma: a phase II trial.

Nature communications·2026
Same author

Measuring What Matters to Patients with Pompe Disease: A Review of Clinical Outcome Assessments for Capturing Treatment Benefits of Innovative Novel Therapies.

Advances in therapy·2026
Same author

Hepatic Yolk Sac Tumor: A Systematic Review of Presentation, Diagnosis, and Treatment.

Journal of gastrointestinal cancer·2025
Same author

Non-bacterial thrombotic endocarditis in ovarian cancer: A systematic review.

Gynecologic oncology reports·2025
Same author

Maintenance with niraparib in patients with stage III, stage IV, chemo-naïve recurrent or platinum-sensitive recurrent uterine serous carcinoma: study protocol for a phase II clinical trial.

BMJ open·2025

Area of Science:

  • Endocrinology
  • Oncology
  • Neoplasms

Background:

  • Hypercalcemia is a common complication of various benign and malignant conditions.
  • Multiple myeloma is a known cause of hypercalcemia.
  • Co-occurrence of hypercalcemia causes is rare but possible.

Observation:

  • A patient with multiple myeloma presented with persistent hypercalcemia despite appropriate treatment.
  • Further investigations revealed elevated parathormone (PTH) levels and scintigraphic evidence of a parathyroid adenoma.
  • This suggests a dual etiology for the hypercalcemia.

Findings:

  • The patient's hypercalcemia resolved after surgical excision of the benign parathyroid adenoma.
  • This case highlights the possibility of concurrent multiple myeloma and primary hyperparathyroidism.

Related Experiment Videos

  • Only 18 similar cases have been reported in the literature.

    • Implications:

    • Clinicians should consider secondary causes of hypercalcemia even after treating the primary malignancy.
    • Elevated PTH levels in hypercalcemic patients with malignancy warrant thorough investigation for parathyroid pathology.
    • This case underscores the importance of comprehensive diagnostic workups for refractory hypercalcemia.