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Updated: Aug 16, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Role of endogenous cannabinoids in cognition and emotionality
1Max-Planck-Institut für Psychiatrie, AG Neuronale Plastizität, Munich, Germany. wotjak@mpipsykl.mpg.de
Abstract:
Novel pharmacological tools and the generation of null-mutants enabled the elucidation of the role of endocannabinoids in cognition and emotionality of rats and mice. Endocannabinoids seem to limit memory retention, to facilitate memory extinction and to ensure adequate coping with stressful situations. A selective potentiation of these actions may lead to novel pharmacotherapies for human anxiety disorders.
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