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Updated: Aug 16, 2026

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
[Preliminary study on genotype of hepatitis B virus detected from Tibetans in China]
Yan-qing Xu1, Yong-dong Zhou, Sheng-li Bi
1Department of Hepatitis Virus, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
Objective:
To determine the main genotype of hepatitis B virus (HBV) detected from Tibetans in China and provide basic data for hepatitis control and prevention.
Methods:
The S gene and C gene were amplified by PCR from the sera of HBsAg positive Tibetans. After sequencing, the gene sequences were analyzed and the phylogenetic trees were drawn by the software MEGA3.
Results:
In trees based on S gene, the sequences of most samples clustered at genotype D, while in trees based on C gene, the sequences of all samples clustered at genotype C.
Conclusion:
The dominant genotype of HBV detected from Tibetans in China is a C/D hybrid.
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